TBX4

TBX4
Identifiers
Aliases	TBX4, SPS, ICPPS, T-box 4, T-box transcription factor 4, PAPPAS
External IDs	OMIM: 601719; MGI: 102556; HomoloGene: 7968; GeneCards: TBX4; OMA:TBX4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	61,485,110 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	85,806,923 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; Achilles tendon; ; cartilage tissue; ; tibial arteries; ; lower lobe of lung; ; urinary bladder; ; placenta; ; prostate; ; gallbladder;
	Top expressed in
	secondary oocyte; ; zygote; ; allantois; ; left lung lobe; ; primary oocyte; ; right lung; ; right lung lobe; ; human penis; ; genital tubercle; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	morphogenesis of an epithelium; skeletal system morphogenesis; limb morphogenesis; embryonic limb morphogenesis; angiogenesis; transcription, DNA-templated; lung development; regulation of transcription, DNA-templated; multicellular organism development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9496
	21387
	ENSG00000121075
	ENSMUSG00000000094
	P57082
	P70325
	NM_018488; NM_001321120
	NM_011536; NM_172798
	NP_001308049; NP_060958
	NP_035666; NP_766386
	Wikidata
View/Edit Human	View/Edit Mouse

T-box transcription factor Tbx4 is a transcription factor that belongs to T-box gene family that is involved in the regulation of embryonic developmental processes. The transcription factor is encoded by the TBX4 gene located on human chromosome 17. Tbx4 is known mostly for its role in the development of the hindlimb, but it also plays a critical role in the formation of the umbilicus. Tbx4 has been shown to be expressed in the allantois, hindlimb, lung and proctodeum.