T-box

For the riboswitch family, see T-box leader.
For uses of the unhyphenated form, see Tbox (disambiguation).
T-box
Crystallographic structure of the TBX3 protein dimer (cyan and green) complexed with DNA (brown) based on the PDB: 1h6f​ coordinates.
Identifiers
SymbolT-box
PfamPF00907
InterProIPR001699
PROSITEPS50252
SCOP21xbr / SCOPe / SUPFAM
Available protein structures:
PDB  1h6f​, 1xbr​ IPR001699 PF00907 (ECOD; PDBsum)  
AlphaFold

T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT.

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