Syncytin-2

ERVFRD-1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y4M
Identifiers
Aliases	ERVFRD-1, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
External IDs	OMIM: 610524; MGI: 3045308; HomoloGene: 86779; GeneCards: ERVFRD-1; OMA:ERVFRD-1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	11,111,725 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	69,531,748 bp
RNA expression pattern
	Top expressed in
	placenta; ; tendon of biceps brachii; ; retinal pigment epithelium; ; gallbladder; ; right adrenal cortex; ; fundus; ; left adrenal gland; ; left adrenal cortex; ; smooth muscle tissue; ; urinary bladder;
	Top expressed in
	placenta; ; chorion; ; ovary; ; jejunum;
	More reference expression data
	n/a
Orthologs
	405754
	239167
	ENSG00000244476
	ENSMUSG00000047977
	P60508
	Q8BI41
	NM_207582
	NM_173420
	NP_997465
	NP_775596
	Wikidata
View/Edit Human	View/Edit Mouse

Syncytin-2 also known as endogenous retrovirus group FRD member 1 is a protein that in humans is encoded by ERVFRD-1 gene. It is a member of the HERV-FRD family of endogenous retroviral elements. The human ERVFRD-1 gene is located on chromosome 6. Both Syncytin-2 and Syncytin-1 are encoded by ENV genes and were first identified in a human placenta. Specifically, Syncytin-2 was observed in the cytoplasmic membrane of primary trophoblast cells in the placenta.

The receptor for this fusogenic env protein is ASCT-2 and the transporter is MFSD-2. In studies conducted that observed the protein interactions with this receptor, it was additionally found that Syncytin-2 signals were detected at the membrane. This is a place of cell-to-cell contact where this protein can interact with its receptor, in order to be able to induce fusion.