Cell–cell fusogens

Cell–cell fusion
Identifiers
SymbolEFF-AFF
PfamPF14884
InterProIPR029213
Available protein structures:
PDB  IPR029213 PF14884 (ECOD; PDBsum)  
AlphaFold

Cell–cell fusogens are glycoproteins that facilitate the fusion of cell to cell membranes. Cell–cell fusion is critical for the merging of gamete genomes and the development of organs in multicellular organisms. Cell-cell fusion occurs when both actin cytoskeleton and fusogenic proteins properly rearrange across the cell membrane. This process is led by actin-propelled membrane protrusions.