SKF-82,958

SKF-82,958
Clinical data
Other names	SKF-82958; SKF82958; SK&F-82958; SK&F-82,958
Drug class	Dopamine D1-like receptor agonist
ATC code	None;
Identifiers
	IUPAC name 3-allyl-6-chloro-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;
CAS Number	80751-65-1;
PubChem CID	1225;
ChemSpider	1188;
UNII	7W60FE897Q;
ChEMBL	ChEMBL317741;
CompTox Dashboard (EPA)	DTXSID70894837 ;
Chemical and physical data
Formula	C19H20ClNO2
Molar mass	329.82 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C=CCN1CCC2=C(C(=C(C=C2C(C1)C3=CC=CC=C3)O)O)Cl;
	InChI InChI=1S/C19H20ClNO2/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13/h2-7,11,16,22-23H,1,8-10,12H2/t16-/m1/s1; Key:HJWHHQIVUHOBQN-MRXNPFEDSA-N;

SKF-82,958 is a synthetic compound of the 3-benzazepine family that acts as a dopamine D₁ and D₅ receptor full agonist. SKF-82,958 and similar D₁-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine. SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.