Estrogen receptor beta

ESR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J26, 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4ZI1
Identifiers
Aliases	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, estrogen receptor 2, ODG8
External IDs	OMIM: 601663; MGI: 109392; HomoloGene: 1100; GeneCards: ESR2; OMA:ESR2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	64,338,112 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,224,033 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; secondary oocyte; ; left ovary; ; right ovary; ; granulocyte; ; epithelium of colon; ; left testis;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; urethra; ; female urethra; ; male urethra; ; cumulus cell; ; lumbar subsegment of spinal cord; ; embryo; ; ovary;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nuclear receptor activity; metal ion binding; steroid hormone receptor activity; steroid binding; zinc ion binding; protein binding; DNA binding; sequence-specific DNA binding; transcription coactivator activity; receptor antagonist activity; lipid binding; enzyme binding; estrogen response element binding; core promoter sequence-specific DNA binding; estrogen receptor activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	mitochondrion; nucleus; nucleoplasm; extracellular region;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of cell growth; transcription initiation from RNA polymerase II promoter; positive regulation of DNA-binding transcription factor activity; cell-cell signaling; signal transduction; extracellular negative regulation of signal transduction; positive regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; intracellular estrogen receptor signaling pathway; positive regulation of transcription by RNA polymerase II; cellular response to estradiol stimulus; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2100
	13983
	ENSG00000140009
	ENSMUSG00000021055
	Q92731
	O08537
NM_001040275; NM_001040276; NM_001214902; NM_001214903; NM_001271876;
	NM_001271877; NM_001291712; NM_001291723; NM_001437
	NM_010157; NM_207707
NP_001035365; NP_001201831; NP_001258805; NP_001258806; NP_001278641;
	NP_001278652; NP_001428
	NP_034287; NP_997590
	Wikidata
View/Edit Human	View/Edit Mouse

Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor—a nuclear receptor which is activated by the sex hormone estrogen. In humans ERβ is encoded by the ESR2 gene.