Rasburicase

Rasburicase
Clinical data
Trade names	Elitek, Fasturtec
AHFS/Drugs.com	Monograph
License data	US DailyMed: Rasburicase;
Pregnancy; category	AU: B2; ;
Routes of; administration	Intravenous infusion
ATC code	V03AF07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	N/A
Elimination half-life	18 hrs
Identifiers
	IUPAC name Aspergillus urate oxidase;
CAS Number	134774-45-1 ;
IUPHAR/BPS	7467;
DrugBank	DB00049 ;
ChemSpider	none;
UNII	08GY9K1EUO;
KEGG	D05704;
ChEMBL	ChEMBL1201594 ;
ECHA InfoCard	100.207.686
Chemical and physical data
Formula	C1521H2381N417O461S7
Molar mass	34109.66 g·mol−1
	(what is this?) (verify)

Rasburicase, sold under the brand name Elitek in the US and Fasturtec in the EU, is a medication that helps to clear uric acid from the blood. It is a recombinant version of urate oxidase, an enzyme that metabolizes uric acid to allantoin. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. Rasburicase is produced by a genetically modified Saccharomyces cerevisiae strain. The complementary DNA (cDNA) coding for rasburicase was cloned from a strain of Aspergillus flavus.

Rasburicase (Q00511) is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek (rasburicase) is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.

It is on the World Health Organization's List of Essential Medicines.