Urate oxidase

UOX
Identifiers
AliasesUOX, UOXP, URICASE, Urate oxidase, urate oxidase (pseudogene)
External IDsMGI: 98907; GeneCards: UOX; OMA:UOX - orthologs
Orthologs
SpeciesHumanMouse
Entrez

391051

22262

Ensembl

ENSG00000240520

ENSMUSG00000028186

UniProt

n
a

P25688

RefSeq (mRNA)

n/a

NM_009474

RefSeq (protein)

n/a

NP_033500

Location (UCSC)n/aChr 3: 146.28 – 146.34 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

The enzyme urate oxidase (UO), also known as uricase or factor-independent urate hydroxylase, is found in nearly all species from bacteria to mammals, but is not expressed in humans, great apes, and certain New World monkeys, in which it exists as a pseudogene. It catalyzes the oxidation of uric acid to 5-hydroxyisourate:

Uric acid + O2 + H2O → 5-hydroxyisourate + H2O2
5-hydroxyisourate + H2O → 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline → allantoin + CO2
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