Quingestanol acetate

Quingestanol acetate
Clinical data
Trade names	Demovis, Pilomin, others
Other names	W-4540; Norethisterone acetate 3-cyclopentyl enol ether; 17α-Ethynyl-19-nortestosterone acetate 3-cyclopentyl enol ether; ENTACP; (17β)-3-(Cyclopentyloxy)-17-ethynylestra-3,5-dien-17-yl acetate
Routes of; administration	By mouth
Drug class	Progestogen; Progestin; Progestogen ester
ATC code	G03AC04 (WHO) ; G03AA02 (WHO) (with an estrogen);
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name [(8R,9S,10R,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-2,7,8,9,10,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;
CAS Number	3000-39-3;
PubChem CID	18142;
DrugBank	DB14679;
ChemSpider	17136;
UNII	M33GGZ63KG;
ChEBI	CHEBI:135661;
ChEMBL	ChEMBL2105291;
CompTox Dashboard (EPA)	DTXSID50952409 ;
ECHA InfoCard	100.019.163
Chemical and physical data
Formula	C27H36O3
Molar mass	408.582 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O[C@@]5(C#C)CC[C@@H]4[C@]5(C)CC[C@@H]3[C@@H]2C(\C=C(\OC1CCCC1)CC2)=C/C[C@H]34)C;
	InChI InChI=1S/C27H36O3/c1-4-27(30-18(2)28)16-14-25-24-11-9-19-17-21(29-20-7-5-6-8-20)10-12-22(19)23(24)13-15-26(25,27)3/h1,9,17,20,22-25H,5-8,10-16H2,2-3H3/t22-,23+,24+,25-,26-,27-/m0/s1; Key:FLGJKPPXEKYCBY-AKCFYGDASA-N;

Quingestanol acetate, sold under the brand names Demovis and Pilomin among others, is a progestin medication which was used in birth control pills but is no longer marketed. It is taken by mouth.

Quingestanol acetate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity and no other important hormonal activity. The medication is a prodrug of norethisterone in the body, with quingestanol and norethisterone acetate occurring as intermediates.

Quingestanol acetate was patented in 1963 and was introduced for medical use in 1972. It was marketed in Italy.