Progesterone receptor

PGR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0
Identifiers
Aliases	PGR, NR3C3, PR, progesterone receptor
External IDs	OMIM: 607311; MGI: 97567; HomoloGene: 713; GeneCards: PGR; OMA:PGR - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	101,129,813 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	8,968,612 bp
RNA expression pattern
	Top expressed in
	endometrium; ; germinal epithelium; ; canal of the cervix; ; body of uterus; ; right uterine tube; ; tail of epididymis; ; myometrium; ; seminal vesicula; ; ectocervix; ; right ventricle;
	Top expressed in
	gastrula; ; decidua; ; substantia nigra; ; uterus; ; ventromedial nucleus; ; facial motor nucleus; ; arcuate nucleus; ; anterior amygdaloid area; ; prefrontal cortex; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; ATPase binding; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; steroid binding; protein binding; enzyme binding; signaling receptor binding; lipid binding; nuclear receptor activity; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; membrane; nucleoplasm; mitochondrial outer membrane; mitochondrion; nucleus; cytosol;
Biological process	regulation of transcription, DNA-templated; cell-cell signaling; negative regulation of gene expression; transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; signal transduction; steroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; ovulation from ovarian follicle; epithelial cell maturation; mammary gland development; paracrine signaling; lung alveolus development; regulation of epithelial cell proliferation; progesterone receptor signaling pathway; tertiary branching involved in mammary gland duct morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5241
	18667
	ENSG00000082175
	ENSMUSG00000031870
	P06401
	Q00175
	NM_000926; NM_001202474; NM_001271161; NM_001271162
	NM_008829
	NP_000917; NP_001189403; NP_001258090; NP_001258091
	NP_032855
	Wikidata
View/Edit Human	View/Edit Mouse

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.

In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has three isoforms: PR-A, PR-B, and PR-C. Though PR-A and PR-B are much more well studied compared to PR-C. The PR-B is the positive regulator of the effects of progesterone, while PR-A serve to antagonize the effects of PR-B.