PRIM2

PRIM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L9Q, 3Q36, 4BPU, 4BPW, 4BPX, 4RR2, 5F0Q, 5EXR, 5F0S
Identifiers
Aliases	PRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDs	OMIM: 176636; MGI: 97758; HomoloGene: 731; GeneCards: PRIM2; OMA:PRIM2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	57,646,850 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	33,708,876 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gonad; ; ganglionic eminence; ; Achilles tendon; ; ventricular zone; ; testicle; ; oocyte; ; epithelium of colon; ; stromal cell of endometrium; ; rectum;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; genital tubercle; ; maxillary prominence; ; primary oocyte; ; mandibular prominence; ; medial ganglionic eminence; ; tail of embryo; ; cumulus cell; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; transferase activity; DNA binding; 4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; nucleotidyltransferase activity; metal ion binding; single-stranded DNA binding; DNA-directed DNA polymerase activity; DNA primase activity; protein binding;
Cellular component	nucleoplasm; alpha DNA polymerase:primase complex;
Biological process	DNA replication; DNA replication, synthesis of RNA primer; DNA biosynthetic process; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	5558
	19076
	ENSG00000146143
	ENSMUSG00000026134
	P49643
	P33610
	NM_000947; NM_001282487; NM_001282488
	NM_008922
	NP_000938; NP_001269416; NP_001269417
	NP_032948
	Wikidata
View/Edit Human	View/Edit Mouse

DNA primase large subunit in humans is encoded by the PRIM2 gene and is part of the enzyme DNA polymerase alpha.

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.