Peroxisome proliferator-activated receptor alpha

PPARA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR, 4CI4, 5AZT
Identifiers
Aliases	PPARA, NR1C1, PPAR, PPARalpha, hPPAR, peroxisome proliferator activated receptor alpha, PPAR-alpha
External IDs	MGI: 104740; HomoloGene: 21047; GeneCards: PPARA; OMA:PPARA - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	46,243,755 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,687,020 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; jejunal mucosa; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; right lobe of liver; ; retinal pigment epithelium; ; muscle of thigh; ; right ventricle; ; body of tongue; ; mucosa of sigmoid colon;
	Top expressed in
	left lobe of liver; ; right kidney; ; intercostal muscle; ; brown adipose tissue; ; digastric muscle; ; human kidney; ; sternocleidomastoid muscle; ; thoracic diaphragm; ; soleus muscle; ; transitional epithelium of urinary bladder;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein domain specific binding; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; ubiquitin conjugating enzyme binding; lipid binding; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; signaling receptor activity; protein-containing complex binding; transcription coactivator binding; phosphatase binding; NFAT protein binding; MDM2/MDM4 family protein binding; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; fatty acid binding; nuclear receptor coactivator activity;
Cellular component	nucleus; nucleoplasm; RNA polymerase II transcription regulator complex;
Biological process	lipoprotein metabolic process; negative regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of fatty acid beta-oxidation; negative regulation of glycolytic process; response to hypoxia; regulation of transcription, DNA-templated; negative regulation of blood pressure; lipid metabolism; rhythmic process; wound healing; negative regulation of leukocyte cell-cell adhesion; negative regulation of transcription by RNA polymerase II; fatty acid transport; negative regulation of protein binding; negative regulation of appetite; circadian regulation of gene expression; transcription, DNA-templated; fatty acid metabolic process; behavioral response to nicotine; positive regulation of transcription, DNA-templated; negative regulation of cholesterol storage; response to insulin; development of the heart; intracellular receptor signaling pathway; negative regulation of transcription regulatory region DNA binding; negative regulation of sequestering of triglyceride; regulation of circadian rhythm; regulation of fatty acid metabolic process; epidermis development; regulation of gene expression; enamel mineralization; positive regulation of gluconeogenesis; transcription initiation from RNA polymerase II promoter; negative regulation of inflammatory response; negative regulation of macrophage derived foam cell differentiation; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; negative regulation of neuron death; positive regulation of fatty acid oxidation; regulation of lipid metabolic process; signal transduction; multicellular organism development; hormone-mediated signaling pathway; cell differentiation; response to lipid; negative regulation of transcription, DNA-templated; negative regulation of cell growth involved in cardiac muscle cell development;
	Sources:Amigo / QuickGO
Orthologs
	5465
	19013
	ENSG00000186951
	ENSMUSG00000022383
	Q07869; Q86SF0
	P23204
NM_001001928; NM_001001929; NM_001001930; NM_005036; NM_032644;
	NM_001362872; NM_001362873; NM_001393941; NM_001393942; NM_001393943; NM_001393944; NM_001393945; NM_001393946; NM_001393947
	NM_001113418; NM_011144
	NP_001001928; NP_005027; NP_001349801; NP_001349802
	NP_001106889; NP_035274
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome proliferator-activated receptor delta and peroxisome proliferator-activated receptor gamma, PPAR-alpha is part of the subfamily of peroxisome proliferator-activated receptors. It was the first member of the PPAR family to be cloned in 1990 by Stephen Green and has been identified as the nuclear receptor for a diverse class of rodent hepato carcinogens that causes proliferation of peroxisomes.