Peroxisome proliferator-activated receptor delta

PPARD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM
Identifiers
Aliases	PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, peroxisome proliferator activated receptor delta
External IDs	OMIM: 600409; MGI: 101884; HomoloGene: 4544; GeneCards: PPARD; OMA:PPARD - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,428,191 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,301,474 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; skin of thigh; ; tail of epididymis; ; buccal mucosa cell; ; amniotic fluid; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; corpus epididymis; ; mucosa of transverse colon; ; placenta;
	Top expressed in
	zygote; ; lip; ; esophagus; ; secondary oocyte; ; interventricular septum; ; muscle of thigh; ; genital tubercle; ; colon; ; granulocyte; ; jejunum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; transcription coactivator activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; fatty acid binding; protein binding; linoleic acid binding; protein heterodimerization activity; lipid binding; DNA-binding transcription factor activity; transcription factor binding; nuclear receptor activity; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; NF-kappaB binding; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; nuclear receptor coactivator activity; signaling receptor activity;
Cellular component	nucleoplasm; nucleus; RNA polymerase II transcription regulator complex;
Biological process	fatty acid catabolic process; positive regulation of myoblast proliferation; positive regulation of epidermis development; cell differentiation; negative regulation of smooth muscle cell proliferation; negative regulation of myoblast differentiation; regulation of transcription, DNA-templated; placenta development; regulation of transcription by RNA polymerase II; negative regulation of smooth muscle cell migration; wound healing; mRNA transcription; cholesterol metabolic process; negative regulation of apoptotic process; response to glucose; response to activity; response to organic substance; generation of precursor metabolites and energy; regulation of fat cell differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; response to vitamin A; development of the heart; cell-substrate adhesion; keratinocyte proliferation; positive regulation of gene expression; proteoglycan metabolic process; regulation of cell population proliferation; negative regulation of cell growth; fatty acid oxidation; positive regulation of cell population proliferation; glucose metabolic process; phospholipid biosynthetic process; negative regulation of epithelial cell proliferation; positive regulation of skeletal muscle tissue regeneration; apoptotic signaling pathway; vitamin A metabolic process; positive regulation of phosphatidylinositol 3-kinase signaling; keratinocyte migration; adipose tissue development; transcription initiation from RNA polymerase II promoter; regulation of skeletal muscle satellite cell proliferation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-templated; negative regulation of inflammatory response; cellular response to lipopolysaccharide; cellular response to hypoxia; negative regulation of collagen biosynthetic process; positive regulation of insulin secretion; steroid hormone mediated signaling pathway; apoptotic process; cell population proliferation; negative regulation of transcription by RNA polymerase II; intracellular receptor signaling pathway; axon ensheathment; decidualization; fatty acid transport; embryo implantation; negative regulation of pri-miRNA transcription by RNA polymerase II; lipid metabolism; fatty acid beta-oxidation; glucose transmembrane transport; fatty acid metabolic process; multicellular organism development; hormone-mediated signaling pathway; negative regulation of cholesterol storage; regulation of lipid metabolic process; response to lipid; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5467
	19015
	ENSG00000112033
	ENSMUSG00000002250
	Q03181
	P35396
	NM_001171818; NM_001171819; NM_001171820; NM_006238; NM_177435
	NM_011145
	NP_001165289; NP_001165290; NP_001165291; NP_006229; NP_803184
	NP_035275
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that in humans is encoded by the PPARD gene.

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. It was first identified in Xenopus in 1993.