List of tallest buildings in Louisville

Louisville is the largest city in the U.S. state of Kentucky, with a metropolitan area population of over 1.3 million. Louisville is home to 25 buildings that stand over 200 feet (61 m) tall as of 2026, 12 of which exceed 300 feet (91 m) in height. Two skyscrapers reach a height of 492 ft (150 m), the most in Kentucky and the second most of any city in the East South Central states, after Nashville. The tallest building in Louisville and in Kentucky is 400 West Market, which was built in 1992 and is 549 ft (167.3 m) tall. The skyscraper is known for its 80-foot (24 m) high Romanesque dome. The second tallest building in Louisville is PNC Tower, which was formerly the city's tallest building from 1972 to 1992.

The ten-story Columbia Building, built in 1890, is considered to be the city's first skyscraper. The 236 ft (72 m), 19-story Kentucky Home Life Building became the tallest building in Louisville when it was completed in 1912, and it was surpassed by the 250 ft (76 m) Heyburn Building in 1928. The designs of both buildings were influenced by neoclassical architecture. Following the onset of the Great Depression, skyscraper development stalled over the next two decades. In 1955, the Commonwealth Building became the tallest in Louisville after a 17-story vertical addition was built on top of the existing four-story structure.

A construction boom took place from the 1960s and 1980s. The 800 Apartments, a 29-story residential tower, became the city's tallest building when it opened in 1963. 500 West Jefferson was the first building in Louisville to reach a height of 400 ft (122 m) in 1971, though it was surpassed by PNC Tower a year later. The 1980s saw the addition of taller office buildings such as B&W Tower in 1982 and the Humana Building in 1985, both taller than 300 ft (91 m), culminating in the construction of 400 West Market and the Waterfront Plaza twin towers in the early 1990s. Since then, the rate of high-rise construction in Louisville has declined. Significant projects in the 21st century include Waterfront Park Place, a 23-story residential tower built in 2004, and Omni Louisville Hotel, the city's fifth tallest building at 370 ft (113 m), in 2018.

Most of Louisville's tallest buildings are situated in Downtown Louisville, which is south of the Ohio River. Downtown Louisville is bounded by Interstate 64 to the north, while Interstate 65 runs through the east of downtown. The University of Louisville School of Medicine has its main campus in the southeast of downtown. The campus and the surrounding hospitals include several high-rises.