Kentucky Home Life Building

Inter-Southern Insurance Building
Interactive map of Inter-Southern Insurance Building
Location239 South 5th St.
Louisville, Kentucky 40202
Coordinates38°15′15″N 85°45′30″W / 38.25419°N 85.75847°W / 38.25419; -85.75847
Built1912
ArchitectBrinton B. Davis (original building)
D.X. Murphy & Brother (1922 addition)
Architectural styleNeoclassical
NRHP reference No.80001605
Added to NRHPMarch 19, 1980

The Kentucky Home Life Building, formerly the Inter-Southern Life Insurance Building, is a 20-floor, 235-foot (72-m) building in downtown Louisville, Kentucky, United States. It was the tallest building in Louisville until the construction of the Heyburn Building in 1927. The Kentucky Home Life Building was added to the National Register of Historic Places in 1980.

The building has historically housed office space for lawyers, accountants and other professionals. It sits at the corner of 5th and Jefferson streets – across from Louisville Metro Hall and close to many other city government and private offices – and contains more than 274,000 square feet of office space. As of 2025, the building was reportedly vacant and undergoing foreclosure, and developers have proposed renovations for mixed-use.