LY-2459989

LY-2459989
Clinical data
Routes of; administration	Oral, intravenous
ATC code	None;
Pharmacokinetic data
Elimination half-life	15 minutes (in rhesus monkeys)
Identifiers
	IUPAC name 3-Fluoro-4-[4-[[(2S)-2-pyridin-3-ylpyrrolidin-1-yl]methyl]phenoxy]benzamide;
CAS Number	2254067-61-1 ;
PubChem CID	134819873;
ChemSpider	81367627;
UNII	2X23M5HP34;
ChEMBL	ChEMBL5499267;
CompTox Dashboard (EPA)	DTXSID201045938 ;
Chemical and physical data
Formula	C23H22FN3O2
Molar mass	391.446 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c4cccnc4)cc2)c(F)c1;
	InChI InChI=1S/C23H22FN3O2/c24-20-13-17(23(25)28)7-10-22(20)29-19-8-5-16(6-9-19)15-27-12-2-4-21(27)18-3-1-11-26-14-18/h1,3,5-11,13-14,21H,2,4,12,15H2,(H2,25,28)/t21-/m0/s1; Key:DRGHCUTTXWIERB-NRFANRHFSA-N;

LY-2459989 is a silent antagonist of the κ-opioid receptor (KOR) that has been developed by Eli Lilly as a radiotracer of that receptor, labeled either with carbon-11 or fluorine-18.