Isotonitazene

Isotonitazene
Clinical data
Routes of; administration	By mouth, nasal spray, e-vape
Legal status
Legal status	BR: Class F1 (Prohibited narcotics); DE: Anlage II (Authorized trade only, not prescriptible); UK: Under Psychoactive Substances Act; US: Schedule I; Illegal in Belgium, Finland and Sweden;
Identifiers
	IUPAC name N,N-diethyl-2-[2-[(4-isopropoxyphenyl)methyl]-5-nitro-benzimidazol-1-yl]ethanamine;
CAS Number	14188-81-9;
PubChem CID	145721979;
ChemSpider	73962294;
UNII	ZFY1ZBQ8AV;
KEGG	C22725;
ChEBI	CHEBI:234360;
CompTox Dashboard (EPA)	DTXSID201126188 ;
Chemical and physical data
Formula	C23H30N4O3
Molar mass	410.518 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CCn1c(Cc2ccc(cc2)OC(C)C)nc2c1ccc(c2)N(=O)=O)CC;
	InChI InChI=1S/C23H30N4O3/c1-5-25(6-2)13-14-26-22-12-9-19(27(28)29)16-21(22)24-23(26)15-18-7-10-20(11-8-18)30-17(3)4/h7-12,16-17H,5-6,13-15H2,1-4H3; Key:OIOQREYBGDAYGT-UHFFFAOYSA-N;

Isotonitazene is a synthetic opioid analgesic drug from the nitazene class and structural homolog of etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans). Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl.