U.S. Route 78 in Mississippi

This article is about the section of U.S. Route 78 in Mississippi. For the entire route, see U.S. Route 78.
"Interstate 22 in Mississippi" redirects here. For the entire length of the highway, see Interstate 22.
U.S. Highway 78
Route information
Maintained by MDOT
Length117.4 mi (188.9 km)
ExistedNovember 11, 1926–present
Major junctions
West end US 78 / SR 4 at the Tennessee state line in Mineral Wells
Major intersections
East end I-22 / US 78 / SR 4 at the Alabama state line near Tremont
Location
CountryUnited States
StateMississippi
CountiesDeSoto, Marshall, Benton, Union, Pontotoc, Lee, Itawamba
Highway system
← MS 76→ US 80
← MS 172MS 178→ MS 182

U.S. Highway 78 (US 78) is a 117.4 miles (188.9 km) east-west controlled-access highway in northern Mississippi. The section from its intersection with Interstate 269 (I-269) in Byhalia to the Alabama state line runs concurrently with I-22. The highway runs across the northeastern rural part of the state, connecting several population centers.

Mississippi's portion of US 78 is defined in Mississippi Code Annotated § 65-3-3.

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