ITCH

Itch
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1YIU, 2JO9, 2JOC
Identifiers
Aliases	6720481N21Rik8030492O04RikA130065M08AIP4C230047C07RikitchyE3 ubiquitin protein ligase
External IDs	HomoloGene: 88442; GeneCards: [1]; OMA:- orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	155,068,775 bp
RNA expression pattern
	Top expressed in
	Rostral migratory stream; ; genital tubercle; ; mesenteric lymph nodes; ; calvaria; ; hand; ; jejunum; ; tail of embryo; ; lacrimal gland; ; epithelium of small intestine; ; right kidney;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity; transferase activity; ligase activity; ribonucleoprotein complex binding; CXCR chemokine receptor binding; ubiquitin protein ligase activity; ubiquitin-like protein ligase binding; arrestin family protein binding;
Cellular component	cytosol; ubiquitin ligase complex; plasma membrane; cell cortex; cytoplasmic vesicle; nucleus; cytoplasm; nucleoplasm; early endosome; endosome; endosome membrane; early endosome membrane; membrane; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	positive regulation of protein catabolic process; immune system process; protein polyubiquitination; regulation of protein deubiquitination; negative regulation of JNK cascade; negative regulation of alpha-beta T cell proliferation; positive regulation of T cell anergy; defense response to virus; protein ubiquitination; innate immune response; negative regulation of NF-kappaB transcription factor activity; apoptotic process; negative regulation of apoptotic process; negative regulation of defense response to virus; protein K48-linked ubiquitination; ubiquitin-dependent protein catabolic process; protein K29-linked ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; protein autoubiquitination; positive regulation of receptor catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	16396
	n/a
	ENSMUSG00000027598
	n/a
	Q8C863
	Q8C863
	NM_001243712; NM_008395
	n/a
	NP_001230641; NP_032421
	NP_001230641; NP_032421
	Wikidata
View/Edit Human

ITCH is a HECT domain–containing E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H (aka Itchy) mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. The ITCH gene is located on chromosome 20 in humans. ITCH contains a C2 domain, proline-rich region, WW domains, HECT domain, and multiple amino acids that are phosphorylated and ubiquitinated.