C2 domain

Phosphoinositide 3-kinase C2
Phosphoinositide 3-kinase C2
	Structure of phosphoinositide 3-kinase.
Identifiers
Symbol	PI3K_C2
Pfam	PF00792
Pfam clan	CL0154
ECOD	11.2.1
InterPro	IPR002420
SMART	PI3K_C2
PROSITE	PDOC50004
SCOP2	1e8x / SCOPe / SUPFAM
CDD	cd08380
PDB
Available protein structures:
PDB	1e7u, 1e7v, 1e8w, 1e8x, 1e8y, 1e8z, 1e90, 1he8, 2a4z, 2a5u, 2chw, 2chx, 2chz, 2rd0, 2v4l, 3csf, 3cst, 3dbs, 3dpd, 3ene IPR002420 PF00792 (ECOD; PDBsum)
AlphaFold	IPR002420; PF00792;

Available protein structures:
PDB	IPR000008 PF00168 (ECOD; PDBsum)
AlphaFold	IPR000008; PF00168;

C2 domain
C2 domain
	The C2-domain of C.absonum α-toxin (PDB 1OLP). β-strands are shown in yellow, α-helices in red, loops in green. Co-ordinated calcium ions are in cyan.
Identifiers
Symbol	C2
Pfam	PF00168
Pfam clan	CL0154
ECOD	11.2.1
InterPro	IPR000008
SMART	C2
PROSITE	PDOC00380
SCOP2	1qas / SCOPe / SUPFAM
OPM superfamily	45
OPM protein	1ugk
CDD	cd00030
PDB
Available protein structures:
PDB	IPR000008 PF00168 (ECOD; PDBsum)
AlphaFold	IPR000008; PF00168;

A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity.