HU-243

HU-243
Identifiers
	IUPAC name (6aR,8S,9S,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-8,9-ditritio-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-1-ol;
CAS Number	140835-18-3 ;
PubChem CID	3081854;
IUPHAR/BPS	735;
ChemSpider	2339369;
UNII	SKGOA1RZCT;
CompTox Dashboard (EPA)	DTXSID701101448 ;
Chemical and physical data
Formula	C25H40O3
Molar mass	388.592 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(O1)(C)[C@H]2[C@@H](C[C@H](CO)CC2)C3=C1C=C(C(C)(C)CCCCCC)C=C3O;
	InChI InChI=1S/C25H40O3/c1-6-7-8-9-12-24(2,3)18-14-21(27)23-19-13-17(16-26)10-11-20(19)25(4,5)28-22(23)15-18/h14-15,17,19-20,26-27H,6-13,16H2,1-5H3/t17-,19-,20-/m1/s1/i10T,17T/t10-,17+,19+,20+/m0; Key:MVEVPDCVOXJVBD-FASICABJSA-N;

HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a methylene homologue of canbisol. It is a potent agonist at both the CB₁ and CB₂ receptors, with a binding affinity of 0.041 nM at the CB₁ receptor, making it marginally more potent than HU-210, which had an affinity of 0.061 nM in the same assay.