Cannabinoid receptor 2

CNR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KI9
Identifiers
Aliases	CNR2, CB-2, CB2, CX5, Cannabinoid receptor type 2, cannabinoid receptor 2
External IDs	OMIM: 605051; MGI: 104650; HomoloGene: 1389; GeneCards: CNR2; OMA:CNR2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	23,913,362 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,647,518 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; tibialis anterior muscle; ; mucosa of ileum; ; granulocyte; ; deltoid muscle; ; blood; ; cecum; ; appendix; ; superior surface of tongue;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; spleen; ; blood; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; thymus; ; tibiofemoral joint; ; right lung lobe; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; cannabinoid receptor activity;
Cellular component	integral component of membrane; perikaryon; cell projection; membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; integral component of plasma membrane; soma; dendrite; neuron projection;
Biological process	negative regulation of nitric-oxide synthase activity; negative regulation of mast cell activation; cannabinoid signaling pathway; response to amphetamine; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of action potential; response to lipopolysaccharide; negative regulation of synaptic transmission, GABAergic; immune response; sensory perception of pain; inflammatory response; negative regulation of inflammatory response; signal transduction; leukocyte chemotaxis; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1269
	12802
	ENSG00000188822
	ENSMUSG00000062585
	P34972
	P47936
	NM_001841
	NM_009924; NM_001305278
	NP_001832
	NP_001292207; NP_034054
	Wikidata
View/Edit Human	View/Edit Mouse

The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It is closely related to the cannabinoid receptor 1 (CB1), which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol (THC), the active agent in cannabis, and other phytocannabinoids (plant cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-Arachidonoylglycerol (2-AG).

CB2 was cloned in 1993 by a research group from Cambridge looking for a second cannabinoid receptor that could explain the pharmacological properties of tetrahydrocannabinol. The receptor was identified among cDNAs based on its similarity in amino acid sequence to the CB1 receptor, discovered in 1990. The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system.