HLA-A74

HLA-A74
HLA-A74
(MHC Class I, A cell surface antigen)
	HLA-A74
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*74--, β2-microglobulin
Subtypes
Subtype
Subtype	allele
A74	*7401
{{{cNick2}}}	*74{{{cAllele2}}}
{{{cNick3}}}	*74{{{cAllele3}}}
{{{cNick4}}}	*74{{{cAllele4}}}
Rare alleles
Subtype
Subtype	allele
A74.3	*7403
{{{rnick2}}}	*74{{{rallele2}}}
{{{rnick3}}}	*74{{{rallele3}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁷⁴ subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M locus. A74 and A*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.

A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.

Serotype

A74 recognition of some HLA A*74 gene products
A*74	A74	A19	Sample
allele	%	%	size (N)
*7401	40	11	119
*7403	17	0	29

A74 has a poor serotyping rate.