HLA-A66

HLA-A66
HLA-A66
(MHC Class I, A cell surface antigen)
	HLA-A66
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*66--, β2-microglobulin
Older names	A10
Subtypes
Subtype
Subtype	allele
A66.1	*6601
A66.2	*6602
{{{cNick3}}}	*66{{{cAllele3}}}
{{{cNick4}}}	*66{{{cAllele4}}}
Rare alleles
Subtype
Subtype	allele
A66.3	*6603
{{{rnick2}}}	*66{{{rallele2}}}
{{{rnick3}}}	*66{{{rallele3}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁶ subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus. A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele..

Serotype

A66 recognition of some HLA A*66 gene products
A*66	A66	A10	A26	A34	Sample
allele	%	%	%	%	size (N)
*6601	20	10	61	8	799
*6602	38	10	4	27	205
*6603	32	7	7	18	28

A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.