Florbetapir (¹⁸F)

Florbetapir (¹⁸
F)
Clinical data
Pronunciation	/flɔːrˈbeɪtəpɪər/; flor-BAY-tə-peer
Trade names	Amyvid
Other names	18; F-AV-45, florbetapir-fluorine-18, Florbetapir F 18 (USAN US)
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Florbetapir;
Routes of; administration	Intravenous
ATC code	V09AX05 (WHO) ;
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name 4-[(E)-2-(6-{2-[2-(2-(18; F)Fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)ethen-1-yl]-N-methylaniline;
CAS Number	956103-76-7;
PubChem CID	24822371;
IUPHAR/BPS	7344;
ChemSpider	26348452;
UNII	6W15Z5R0RU;
KEGG	D09617;
CompTox Dashboard (EPA)	DTXSID80241898 ;
Chemical and physical data
Formula	C20H2518FN2O3
Molar mass	359 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC1=CC=C(C=C1)/C=C/C2=CN=C(C=C2)OCCOCCOCC[18F];
	InChI InChI=1S/C20H25FN2O3/c1-22-19-7-4-17(5-8-19)2-3-18-6-9-20(23-16-18)26-15-14-25-13-12-24-11-10-21/h2-9,16,22H,10-15H2,1H3/b3-2+/i21-1; Key:YNDIAUKFXKEXSV-CRYLGTRXSA-N;

Florbetapir (¹⁸
F), sold under the brand name Amyvid, is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18 that was approved for use in the United States in 2012, as a diagnostic tool for Alzheimer's disease. Florbetapir, like Pittsburgh compound B (PiB), binds to beta-amyloid, however fluorine-18 has a half-life of 109.75 minutes, in contrast to PiB's radioactive half life of 20 minutes. The longer life allows the tracer to accumulate significantly more in the brains of people with AD, particularly in the regions known to be associated with beta-amyloid deposits.