FLY (psychedelics)

Not to be confused with FLY (psychedelic).

FLY is a family of phenethylamine and benzofuran psychedelics possessing a benzodifuran or similar ring system. The FLY drugs were so-named because of the resemblance of their chemical structures to flying insects like dragonflies and butterflies. They are analogues of 2,5-dimethoxyphenethylamines in which the 2- and 5-position methoxy groups have been cyclized into furan and/or tetrahydrofuran rings. They may be 2C, DOx, 25-NB, or other FLY versions of psychedelic phenethylamines.

Examples of different types of FLY drugs, in the case of the base psychedelic 2C-B, include 2C-B-FLY, 2C-B-DragonFLY, and 2C-B-ButterFLY, among others. BromoDragonFLY (DOB-DragonFLY) is known for its very high potency and its toxicity in overdose. 2C-B-FLY was Ann Shulgin's favorite psychedelic.

Several of the FLY drugs have been shown to act as potent serotonin 5-HT2 receptor agonists.

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