DCW234

DCW234
Clinical data
Other names	Butyl 4-(butyryloxy)benzoate
Identifiers
	IUPAC name butyl 4-butanoyloxybenzoate;
CAS Number	723759-26-0 ;
PubChem CID	1729084;
ChemSpider	1371590;
UNII	UEQ2HTT5HP;
CompTox Dashboard (EPA)	DTXSID901337100 ;
Chemical and physical data
Formula	C15H20O4
Molar mass	264.321 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCOC(=O)C1=CC=C(C=C1)OC(=O)CCC;
	InChI InChI=1S/C15H20O4/c1-3-5-11-18-15(17)12-7-9-13(10-8-12)19-14(16)6-4-2/h7-10H,3-6,11H2,1-2H3; Key:LMJDPYAJKHNPHR-UHFFFAOYSA-N;

DCW234, also known as butyl 4-(butyryloxy)benzoate, is a synthetic nonsteroidal estrogen and a selective agonist of the ERβ. It shows modest selectivity in terms of affinity and transactivation for the ERβ over the ERα. Its affinity for the ERβ was 3.43 μM and for the ERα was 22.5 μM, while it activated the ERβ and ERα with EC₅₀ values of 1.71–2.5 μM and 19.8–22.5 μM, respectively. As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between 10- and 13-fold.