Cysteine-rich secretory protein

Crisp domain (CRD)
The two domains of a Cysteine-rich secretory protein (CRISP). CAP-like PR-1 domain in white. ShK-like CRD in red. Disulphides in yellow. Glycan chains not shown. (PDB: 1WVR​)
Identifiers
SymbolCrisp
PfamPF08562
Pfam clanCL0213
InterProIPR013871
Available protein structures:
PDB  IPR013871 PF08562 (ECOD; PDBsum)  
AlphaFold

Cysteine-rich secretory proteins, often abbreviated as CRISPs, are a group of glycoproteins. They are a subgroup of the CRISP, antigen 5 and Pr-1 (CAP) protein superfamily and also contain a domain related to the ShK toxins. They are substantially implicated in the functioning of the mammalian reproductive system. CRISPs are also found in a variety of snake venoms where they inhibit both smooth muscle contraction and cyclic nucleotide-gated ion channels.

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