Stichodactyla toxin

Kappa-stichotoxin-She3a
Kappa-stichotoxin-She3a
Identifiers
Organism	Stichodactyla helianthus
Symbol	?
UniProt	P29187
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Available protein structures:
PDB	IPR003582 PF01549 (ECOD; PDBsum)
AlphaFold	IPR003582; PF01549;

ShK domain-like
ShK domain-like
	Rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) of an NMR solution structure of the ShK toxin. Sidechains of cysteine residues involved in disulfide linkages are displayed as sticks and the sulfur atoms in these links are colored yellow.
Identifiers
Symbol	ShK
Pfam	PF01549
InterPro	IPR003582
SMART	SM00254
SCOP2	1roo / SCOPe / SUPFAM
TCDB	8.B.14
OPM superfamily	296
OPM protein	2lg4
PDB
Available protein structures:
PDB	IPR003582 PF01549 (ECOD; PDBsum)
AlphaFold	IPR003582; PF01549;

Stichodactyla toxin (ShK, ShkT) is a 35-residue basic peptide from the sea anemone Stichodactyla helianthus that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from Bunodosoma granulifera.

An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases.