Binedaline

Binedaline
Clinical data
Routes of; administration	Oral
ATC code	None;
Legal status
Legal status	In general: unscheduled;
Identifiers
	IUPAC name N,N,N-Trimethyl-N-(3-phenylindol-1-yl)ethane-1,2-diamine;
CAS Number	60662-16-0 ;
PubChem CID	42510;
ChemSpider	38769 ;
UNII	3AVG9P140R;
ChEMBL	ChEMBL2104611 ;
CompTox Dashboard (EPA)	DTXSID20209472 ;
Chemical and physical data
Formula	C19H23N3
Molar mass	293.414 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cccc2c1c(cn2N(CCN(C)C)C)c3ccccc3;
	InChI InChI=1S/C19H23N3/c1-20(2)13-14-21(3)22-15-18(16-9-5-4-6-10-16)17-11-7-8-12-19(17)22/h4-12,15H,13-14H2,1-3H3 ; Key:SXYFFMXPDDGOEK-UHFFFAOYSA-N ;
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Binedaline (also called binodaline or binedaline hydrochloride) is a drug that was investigated as an antidepressant in the 1980s but was never marketed. It acts as a selective norepinephrine reuptake inhibitor (K_i = 25 nM), with relatively insignificant influence on the serotonin (K_i = 847 nM) and dopamine (K_i >= 2 μM) transporters. It has negligible affinity for the α-adrenergic, mACh, H₁, or 5-HT₂ receptors.