Mexicana de Aviación (1921–2010)

Mexicana de Aviación
	Airbus A330
Founded	July 12, 1921
Commenced operations	August 30, 1921
Ceased operations	August 28, 2010
Hubs	Cancún; Guadalajara; Mexico City–Benito Juárez;
Focus cities	Chicago–O'Hare; Los Angeles; Morelia; Tijuana; Zacatecas;
Frequent-flyer program	Mexicana Go
Alliance	Star Alliance (2000–2004); Oneworld (2009–2010);
Subsidiaries	Aerocaribe (1972–2005); AeroCozumel (1978–2002); Aeromonterrey (1991–1995); Mexicana Cargo (1980–1987); MexicanaClick (2005–2010); MexicanaLink (2009–2010);
Fleet size	69 (mainline in 2010)
Parent company	SEDENA
Headquarters	Mexicana de Aviación Tower, Mexico City, Ciudad de Mexico, Mexico
Key people	Gerardo Badin (Conciliator/Administrator)
Website	www.mexicana.gob.mx

Compañía Mexicana de Aviación S.A. de C.V., usually shortened to Mexicana de Aviación, was Mexico's oldest airline and one of the oldest continuously single-branded airlines, inaugurated in 1921. It was Mexico's biggest airline and flag carrier before ceasing operations on August 28, 2010, leaving competitor Aeroméxico as a de facto monopoly.

A revival airline is operated by SEDENA – the Mexican Ministry of Defense, as a state-owned airline. It began operations in December 2023 under the legal name Aerolínea del Estado Mexicano using the Mexicana brand.