2025 Knoxville Challenger
| 2025 Knoxville Challenger | |
|---|---|
| Date | 3–9 November |
| Edition | 21st |
| Surface | Hard (Indoor) |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
| Mitchell Krueger | |
| Doubles | |
| Patrick Harper / Quinn Vandecasteele | |
The 2025 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the 21st edition of the tournament which was part of the 2025 ATP Challenger Tour. It took place in Knoxville, United States between 3 and 9 November 2025.