2025 Challenger Ciudad de Guayaquil – Singles

Singles
2025 Challenger Ciudad de Guayaquil
Champion Daniel Vallejo
Runner-up Juan Pablo Varillas
Score7–5, 6–7(7–9), 6–3
Main article: 2025 Challenger Ciudad de Guayaquil

Federico Agustín Gómez was the defending champion but lost in the semifinals to Juan Pablo Varillas.

Daniel Vallejo won the title after defeating Varillas 7–5, 6–7(7–9), 6–3 in the final.

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