2021 Tennessee Titans season

The 2021 season was the Tennessee Titans' 52nd season in the National Football League (NFL), their 62nd overall, their 25th in the state of Tennessee, and their fourth under head coach Mike Vrabel. After a 34–3 win over the Miami Dolphins in Week 17, the Titans clinched the AFC South for the second consecutive season. It would be the first time since 1960–1962 that the franchise would win its division in back-to-back seasons. The Titans finished 12–5, improving on their 11–5 record from the prior year and earning the AFC's No. 1 seed in the playoffs for the first time since 2008. The season ended with a 19–16 loss to eventual AFC champion Cincinnati Bengals, the third consecutive playoff loss.

Injuries were a significant storyline for the Titans throughout the season. Many standout players missed multiple games, including Derrick Henry, the reigning Offensive Player of the Year. Through the first 7 weeks of the season, Henry not only led the NFL in rushing yards but was on pace to break the Eric Dickerson's single-season rushing record. However, Henry would sustain a foot fracture in Week 8 against the Indianapolis Colts and was forced to miss the final 9 games of the regular season. Offseason acquisition Julio Jones, who was acquired in a major trade after 10 seasons with the Atlanta Falcons, was additionally forced to miss 7 games due to a lingering hamstring injury. The Titans would eventually set an NFL record for most players used in a season with 91 individual players. The Titans' regular season success in spite of these injuries contributed to head coach Mike Vrabel winning the AP NFL Coach of the Year award. As of 2025, this is the most recent season that the Titans have made the playoffs, finished the season in first place in the AFC South and finished the season with a winning record.