2021 San Marino Open – Singles

Singles
2021 San Marino Open
Champion Holger Rune
Runner-up Orlando Luz
Score1–6, 6–2, 6–3
Main article: 2021 San Marino Open

Adrian Ungur was the defending champion when the event was last held in 2014 but chose not to defend his title as he had retired from professional tennis.

Holger Rune won the title after defeating Orlando Luz 1–6, 6–2, 6–3 in the final.

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