1-(1-Naphthyl)piperazine
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| Routes of administration | Oral |
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| Formula | C14H16N2 |
| Molar mass | 212.296 g·mol−1 |
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1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative.
It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well.
In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.
Derivatives of naphthylpiperazine include CSP-2503, F-11,461, S-14506, and S-14671.