F-11461

F-11461
Clinical data
Other names	F-11461; F11461
Identifiers
	IUPAC name 2-[4-[4-[7-(Methoxy-11C)-1-naphthalenyl]-1-piperazinyl]butyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione;
CAS Number	874471-25-7 ;
PubChem CID	10324985;
ChemSpider	9850903 ;
UNII	RKG24J8KJR;
ChEMBL	ChEMBL199824;
Chemical and physical data
Formula	C23H29N5O3
Molar mass	423.517 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1C(=O)C=NN(C1=O)CCCCN2CCN(CC2)C3=CC=CC4=C3C=C(C=C4)OC;
	InChI InChI=InChI=1S/C23H29N5O3/c1-25-22(29)17-24-28(23(25)30)11-4-3-10-26-12-14-27(15-13-26)21-7-5-6-18-8-9-19(31-2)16-20(18)21/h5-9,16-17H,3-4,10-15H2,1-2H3; Key:GKTQBPYMIGXPKG-UHFFFAOYSA-N;

F-11,461 is a naphthylpiperazine drug that acts as an agonist of the 5-HT_1A receptor (K_i = 1.36 nM) that has been used as a radioligand in PET studies. It possesses modest affinity for the 5-HT₇ (K_i = 9.1 nM) and D₄ (K_i = 8.5 nM) receptors, although the interaction of F-11,461 with these receptors is not detectable with PET due to their relative scarcity in the brain.