Zinc Finger 559 (ZNF559) is a protein which in humans is encoded by the ZNF559 gene. ZNF559 is a member of the Krüppel C2H2-type zinc finger protein family, characterized by its 13 C2H2-type zinc finger repeats. These motifs enable the protein to bind DNA in a sequence-specific manner, facilitating transcriptional regulation. Additionally, ZNF559 contains a Krüppel-associated box (KRAB) domain at its N-terminus, a common feature in many zinc finger proteins. The KRAB domain is known to mediate transcriptional repression by interacting with corepressor proteins, such as TRIM28, thereby silencing target gene expression. ZNF559 activity is localized to the nucleus, where it contributes to transcriptional regulation through protein and DNA interactions.