ZEB1

ZEB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E19
Identifiers
Aliases	ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDs	OMIM: 189909; MGI: 1344313; HomoloGene: 31779; GeneCards: ZEB1; OMA:ZEB1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	31,529,814 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	5,775,467 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; decidua; ; optic nerve; ; glutes; ; endothelial cell; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; tendon of biceps brachii; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	internal carotid artery; ; substantia nigra; ; motor neuron; ; external carotid artery; ; semi-lunar valve; ; carotid body; ; ascending aorta; ; Rostral migratory stream; ; suprachiasmatic nucleus; ; Gonadal ridge;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; transcription coactivator activity; zinc ion binding; transcription factor binding; chromatin binding; metal ion binding; protein binding; nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; E-box binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus; nucleoplasm; cytosol;
Biological process	pattern specification process; embryonic skeletal system morphogenesis; regulation of smooth muscle cell differentiation; animal organ development; cell differentiation; semicircular canal morphogenesis; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; regulation of transforming growth factor beta receptor signaling pathway; regulation of T cell differentiation in thymus; central nervous system development; cartilage development; regulation of mesenchymal cell proliferation; embryonic camera-type eye morphogenesis; cochlea morphogenesis; immune response; embryonic morphogenesis; cellular response to amino acid stimulus; cell population proliferation; negative regulation of epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of transcription, DNA-templated; positive regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of endothelial cell differentiation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6935
	21417
	ENSG00000148516
	ENSMUSG00000024238
	P37275
	Q64318
NM_001128128; NM_001174093; NM_001174094; NM_001174095; NM_001174096;
	NM_030751; NM_001323638; NM_001323641; NM_001323642; NM_001323643; NM_001323644; NM_001323645; NM_001323646; NM_001323647; NM_001323648; NM_001323649; NM_001323650; NM_001323651; NM_001323652; NM_001323653; NM_001323654; NM_001323655; NM_001323656; NM_001323657; NM_001323658; NM_001323659; NM_001323660; NM_001323661; NM_001323662; NM_001323663; NM_001323664; NM_001323665; NM_001323666; NM_001323671; NM_001323672; NM_001323673; NM_001323674; NM_001323675; NM_001323676; NM_001323677; NM_001323678
	NM_011546; NM_001360981; NM_001360982
NP_001121600; NP_001167564; NP_001167565; NP_001167566; NP_001167567;
	NP_001310567; NP_001310570; NP_001310571; NP_001310572; NP_001310573; NP_001310574; NP_001310575; NP_001310576; NP_001310577; NP_001310578; NP_001310579; NP_001310580; NP_001310581; NP_001310582; NP_001310583; NP_001310584; NP_001310585; NP_001310586; NP_001310587; NP_001310588; NP_001310589; NP_001310590; NP_001310591; NP_001310592; NP_001310593; NP_001310594; NP_001310595; NP_001310600; NP_001310601; NP_001310602; NP_001310603; NP_001310604; NP_001310605; NP_001310606; NP_001310607; NP_110378
	NP_035676; NP_001347910; NP_001347911
	Wikidata
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Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has seven zinc fingers and one homeodomain. The structure of the homeodomain is shown on the right.