YWHAZ

YWHAZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IB1, 1QJA, 1QJB, 2C1J, 2C1N, 2O02, 2WH0, 3CU8, 3NKX, 3RDH, 4BG6, 4FJ3, 4HKC, 4IHL, 4N7G, 4N7Y, 4N84, 4WRQ, 4ZDR, 1A38, 1A4O, 1A37, 5D2D, 5D3F, 5EXA, 5EWZ
Identifiers
Aliases	YWHAZ, 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS
External IDs	OMIM: 601288; MGI: 109484; HomoloGene: 56528; GeneCards: YWHAZ; OMA:YWHAZ - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	100,953,388 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	36,797,173 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; lateral nuclear group of thalamus; ; ganglionic eminence; ; amniotic fluid; ; mucosa of sigmoid colon; ; human penis; ; prefrontal cortex; ; oral cavity; ; ventricular zone; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	olfactory tubercle; ; anterior amygdaloid area; ; lateral septal nucleus; ; subiculum; ; nucleus accumbens; ; medial dorsal nucleus; ; piriform cortex; ; lateral geniculate nucleus; ; habenula; ; Gonadal ridge;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; transcription factor binding; protein binding; identical protein binding; protein kinase binding; ubiquitin protein ligase binding; RNA binding; cadherin binding; transmembrane transporter binding;
Cellular component	cytoplasm; cytosol; blood microparticle; focal adhesion; melanosome; nucleoplasm; mitochondrion; extracellular exosome; cytoplasmic vesicle membrane; extracellular space; nucleus; vesicle; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse;
Biological process	regulation of mRNA stability; negative regulation of apoptotic process; establishment of Golgi localization; Golgi reassembly; platelet activation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; membrane organization; signal transduction; protein targeting; regulation of cell death; cytokine-mediated signaling pathway; regulation of synapse maturation; synaptic target recognition;
	Sources:Amigo / QuickGO
Orthologs
	7534
	22631
	ENSG00000164924
	ENSMUSG00000022285
	P63104
	P63101
NM_001135699; NM_001135700; NM_001135701; NM_001135702; NM_003406;
	NM_145690
	NM_001253805; NM_001253806; NM_001253807; NM_011740; NM_001356569
NP_001129171; NP_001129172; NP_001129173; NP_001129174; NP_003397;
	NP_663723
	NP_001240734; NP_001240735; NP_001240736; NP_035870; NP_001343498
	Wikidata
View/Edit Human	View/Edit Mouse

14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways. 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases.