Xylazine

Xylazine
Clinical data
Pronunciation	/ˈzaɪləziːn/; ZY-lə-zeen
Trade names	Rompun, Anased, Sedazine, Chanazine, others
AHFS/Drugs.com	International Drug Names
License data	US DailyMed: Xylazine;
Routes of; administration	By mouth, inhalation, subcutaneous, intramuscular, intravenous
ATCvet code	QN05CM92 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: Class C; US: ℞-only; Veterinary Use;
Identifiers
	IUPAC name N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;
CAS Number	7361–61–7 ;
PubChem CID	5707;
IUPHAR/BPS	523;
ChemSpider	5505 ;
UNII	2KFG9TP5V8;
KEGG	D08683 ;
ChEMBL	ChEMBL297362 ;
CompTox Dashboard (EPA)	DTXSID3040643 ;
ECHA InfoCard	100.028.093
Chemical and physical data
Formula	C12H16N2S
Molar mass	220.33 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N\1=C(\SCCC/1)Nc2c(cccc2C)C;
	InChI InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14) ; Key:BPICBUSOMSTKRF-UHFFFAOYSA-N ;
	(what is this?) (verify)

Xylazine is a structural analog of clonidine and an α₂-adrenergic receptor agonist, sold under many trade names worldwide, most notably the Bayer brand name Rompun, as well as Anased, Sedazine and Chanazine.

Xylazine is a common veterinary drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other mammals. In veterinary anesthesia, it is often used in combination with ketamine. Veterinarians also use xylazine as an emetic, especially in cats. Drug interactions vary with different animals.

Xylazine was first investigated for human use in the 1960s in West Germany for antihypertensive effects before being discontinued and marketed as a veterinary sedative. Xylazine’s mechanism of action was discovered in 1981, which led to the creation of other α₂-adrenergic receptor agonists such as medetomidine and dexmedetomidine.

Xylazine has become a commonly abused street drug in the United States where it is known by the street name "tranq", particularly in the territory of Puerto Rico. The drug is used as a cutting agent for heroin and fentanyl.