Sotatercept
| Clinical data | |
|---|---|
| Trade names | Winrevair |
| Other names | ACE-011, MK-7962, sotatercept-csrk |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a624053 |
| License data |
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| Pregnancy category |
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| Routes of administration | Subcutaneous |
| ATC code | |
| Legal status | |
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| Identifiers | |
| CAS Number | |
| DrugBank | |
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| KEGG | |
| Chemical and physical data | |
| Formula | C3448H5264N920O1058S42 |
| Molar mass | 77879.94 g·mol−1 |
Sotatercept, sold under the brand name Winrevair, is a medication used to treat pulmonary arterial hypertension. It inhibits activin signaling using the extracellular domain of the activin type 2 receptor fused with an immunoglobulin Fc domain (ACTRIIA-Fc) as a recombinant fusion protein. It is administered via subcutaneous injection.
The most common side effects include headache, epistaxis (nosebleed), rash, telangiectasia (spider veins), diarrhea, dizziness, and erythema (redness of the skin).
Sotatercept was approved for medical use in the United States in March 2024, and in the European Union in August 2024. The US Food and Drug Administration considers it to be a first-in-class medication.