Acoltremon

Acoltremon
	Molecular structure of acoltremon
	3D representation of an acoltremon molecule
Clinical data
Trade names	Tryptyr
Other names	AVX-012, WS-12
AHFS/Drugs.com	Monograph
MedlinePlus	a625071
License data	US DailyMed: Acoltremon;
Routes of; administration	Eye drop
ATC code	None;
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide;
CAS Number	68489-09-8;
PubChem CID	11266244;
DrugBank	DB19202;
ChemSpider	9441255;
UNII	1L7BVT4Z4Z;
KEGG	D13125;
ChEMBL	ChEMBL2441929;
CompTox Dashboard (EPA)	DTXSID10460636 ;
Chemical and physical data
Formula	C18H27NO2
Molar mass	289.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C;
	InChI InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1; Key:HNSGVPAAXJJOPQ-XOKHGSTOSA-N;

Acoltremon sold under the brand name Tryptyr, is a medication used for the treatment of dry eye syndrome. Acoltremon is a transient receptor potential melastatin 8 (TRPM8) thermoreceptor agonist. It is used as an eye drop.

The most common treatment-emergent adverse event experienced during the clinical studies was instillation site pain (burning or stinging) events.

Acoltremon was approved for medical use in the United States in May 2025.