WIPI protein family

For other uses, see WIPI.

The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins. WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy, and contain a conserved motif for interaction with phospholipids.

Members of this family include:

Protein Gene Aliases Yeast
WIPI-1 WIPI1 WIPI49, FLJ10055 Atg18
WIPI-2 WIPI2 Svp1a, DKFZP434J154 WIPI49-like protein 2 Atg21
WIPI-3 WDR45L 628 protein, WIPI49-like protein
WIPI-4 WDR45 JM5 protein, WDRX1
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