WDR5

WDR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CNX, 2CO0, 2G99, 2G9A, 2GNQ, 2H13, 2H14, 2H68, 2H6K, 2H6N, 2H6Q, 2H9L, 2H9M, 2H9N, 2H9P, 2O9K, 3EG6, 3EMH, 3MXX, 3N0D, 3N0E, 3P4F, 3PSL, 3SMR, 3UR4, 3UVK, 3UVL, 3UVM, 3UVN, 3UVO, 4A7J, 4CY1, 4CY2, 4ERQ, 4ERY, 4ERZ, 4ES0, 4ESG, 4EWR, 4GM3, 4GM8, 4GM9, 4GMB, 4IA9, 4O45, 4QL1, 4Y7R, 5EAL, 5EAP, 5EAR, 4QQE, 5EAM
Identifiers
Aliases	WDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5
External IDs	OMIM: 609012; MGI: 2155884; HomoloGene: 59931; GeneCards: WDR5; OMA:WDR5 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	134,159,968 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,426,547 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; left testis; ; right testis; ; sperm; ; gastrocnemius muscle; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; anterior pituitary; ; secondary oocyte; ; gonad;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; zygote; ; primitive streak; ; medullary collecting duct; ; epiblast; ; granulocyte; ; renal corpuscle; ; somite; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone methyltransferase activity (H3-K4 specific); histone acetyltransferase activity (H4-K8 specific); histone acetyltransferase activity (H4-K5 specific); methylated histone binding; protein binding; histone acetyltransferase activity (H4-K16 specific); histone-lysine N-methyltransferase activity; histone binding;
Cellular component	Set1C/COMPASS complex; intracellular anatomical structure; nucleoplasm; MLL1 complex; MLL3/4 complex; histone acetyltransferase complex; nucleus; histone methyltransferase complex; ciliary basal body;
Biological process	skeletal system development; regulation of transcription, DNA-templated; transcription, DNA-templated; histone H4-K5 acetylation; histone H3-K4 methylation; histone H3 acetylation; histone H4-K16 acetylation; neuron projection development; histone H4-K8 acetylation; cilium assembly; post-translational protein modification; regulation of megakaryocyte differentiation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	11091
	140858
	ENSG00000196363
	ENSMUSG00000026917
	P61964
	P61965
	NM_017588; NM_052821
	NM_080848
	NP_060058; NP_438172
	NP_543124
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.