WARS (gene)

WARS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O5T, 1R6T, 1R6U, 1ULH, 2AKE, 2AZX, 2DR2, 2QUH, 2QUI, 2QUJ, 2QUK
Identifiers
Aliases	WARS1, Tryptophanyl-tRNA synthetase, cytoplasmic, GAMMA-2, IFI53, IFP53, tryptophanyl-tRNA synthetase, HMN9, tryptophanyl-tRNA synthetase 1, WARS
External IDs	OMIM: 191050; MGI: 104630; HomoloGene: 3084; GeneCards: WARS1; OMA:WARS1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,376,805 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,860,100 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; upper lobe of left lung; ; right lung; ; apex of heart; ; appendix; ; islet of Langerhans; ; rectum; ; epithelium of colon; ; stromal cell of endometrium;
	Top expressed in
	gastrula; ; crypt of lieberkuhn of small intestine; ; decidua; ; seminal vesicula; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; medulla oblongata; ; pontine nuclei;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; tryptophan-tRNA ligase activity; kinase inhibitor activity; protein kinase binding; protein domain specific binding; protein homodimerization activity;
Cellular component	extracellular exosome; nucleus; cytoplasm; cytosol; protein-containing complex;
Biological process	regulation of angiogenesis; protein biosynthesis; tRNA aminoacylation for protein translation; angiogenesis; negative regulation of cell population proliferation; tryptophanyl-tRNA aminoacylation; negative regulation of protein phosphorylation; negative regulation of protein kinase activity; positive regulation of gene expression; regulation of protein ADP-ribosylation; positive regulation of protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7453
	22375
	ENSG00000140105
	ENSMUSG00000021266
	P23381
	P32921
	NM_004184; NM_173701; NM_213645; NM_213646
	NM_001164314; NM_001164488; NM_011710
	NP_004175; NP_776049; NP_998810; NP_998811
	NP_001157786; NP_001157960; NP_035840
	Wikidata
View/Edit Human	View/Edit Mouse

Tryptophanyl-tRNA synthetase, cytoplasmic is an aminoacyl-tRNA synthetase enzyme that attaches the amino acid tryptophan to its cognate tRNA. In humans, it is encoded by the WARS gene.

Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.