Vitamin B12 total synthesis

The total synthesis of vitamin B12 (cobalamin) was accomplished in 1972 by two different approaches between the collaborating research groups of Robert Burns Woodward at Harvard and Albert Eschenmoser at ETH. The synthetic endeavor required the effort of 91 postdoctoral researchers (77 from Harvard, 14 from ETH), and 12 PhD students (from ETH) over a period of almost 12 years. The synthesis project induced and involved a major paradigm shift in the field of natural product synthesis.

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