Vesicle-associated membrane protein 8

VAMP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WY4
Identifiers
Aliases	VAMP8, EDB, VAMP-8, vesicle associated membrane protein 8
External IDs	OMIM: 603177; MGI: 1336882; HomoloGene: 37846; GeneCards: VAMP8; OMA:VAMP8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,582,031 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,367,686 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; monocyte; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; granulocyte; ; jejunal mucosa; ; rectum; ; nasal epithelium; ; bronchial epithelial cell; ; skin of abdomen;
	Top expressed in
	proximal tubule; ; right kidney; ; yolk sac; ; granulocyte; ; lung; ; bone marrow; ; human kidney; ; urinary bladder; ; duodenum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; protein binding; chloride channel inhibitor activity; SNARE binding;
Cellular component	cytoplasm; integral component of membrane; recycling endosome; vesicle; cytosol; endosome; early endosome membrane; membrane; secretory granule membrane; late endosome membrane; plasma membrane; mucin granule; lysosomal membrane; SNARE complex; early endosome; perinuclear region of cytoplasm; lysosome; extracellular exosome; clathrin-coated vesicle membrane; phagocytic vesicle membrane; azurophil granule membrane; specific granule membrane; recycling endosome membrane; tertiary granule membrane; synaptic vesicle;
Biological process	post-Golgi vesicle-mediated transport; autophagy; autophagosome maturation; negative regulation of secretion by cell; protein transport; viral entry into host cell; vesicle fusion; eosinophil degranulation; vesicle-mediated transport; mucus secretion; regulation of protein localization to plasma membrane; positive regulation of histamine secretion by mast cell; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; autophagosome membrane docking; neutrophil degranulation; membrane organization; regulation of molecular function; transport;
	Sources:Amigo / QuickGO
Orthologs
	8673
	22320
	ENSG00000118640
	ENSMUSG00000050732
	Q9BV40
	O70404
	NM_003761
	NM_016794
	NP_003752
	NP_058074
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex. Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.

In pancreatic β-cells, VAMP8 has been shown to be part of the endosomal system. It is particularly localized to Rab11 recycling endosomes, where it plays an important role in GLP1R and GLUT2 recycling. Overexpression of VAMP8 in β-cells results in decreased insulin secretion.