Uterine serous carcinoma

Uterine papillary serous carcinoma
Other namesUterine papillary serous carcinoma and Uterine serous adenocarcinoma
Histology H&E of uterine serous papillary carcinoma. H&E stain.

Uterine serous carcinoma, previously called uterine papillary serous carcinoma, is a malignant form of serous tumor that originates in the uterus. It is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy, prompted by post-menopausal bleeding.

Despite the name, it is a cancer of the endometrium, which is the inner layer of the uterus; and not of the serous membrane that forms the outer layer of the uterus. The name arises from its histological similarity to serous ovarian cancer.

Unlike the more common low-grade endometrioid endometrial adenocarcinoma, uterine serous carcinoma does not develop from endometrial hyperplasia and is not hormone-sensitive. It arises in the setting of endometrial atrophy and is classified as a type II endometrial cancer.

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