UNC13A

UNC13A
Identifiers
Aliases	UNC13A, Munc13-1, unc-13 homolog A (C. elegans), unc-13 homolog A
External IDs	OMIM: 609894; MGI: 3051532; HomoloGene: 11279; GeneCards: UNC13A; OMA:UNC13A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,688,365 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,124,401 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; beta cell; ; olfactory bulb; ; right frontal lobe; ; prefrontal cortex; ; superior frontal gyrus; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; pituitary gland;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; primary motor cortex; ; neural layer of retina; ; cerebellar cortex; ; piriform cortex; ; prefrontal cortex; ; hippocampus proper; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	syntaxin-1 binding; metal ion binding; diacylglycerol binding; calmodulin binding; calcium ion binding; phospholipid binding;
Cellular component	cytoplasm; membrane; neuromuscular junction; plasma membrane; synapse; axon; cell junction; neuron projection; presynaptic membrane; presynapse; terminal bouton; calyx of Held; presynaptic active zone; glutamatergic synapse; synaptic vesicle membrane; presynaptic active zone cytoplasmic component;
Biological process	cell differentiation; intracellular signal transduction; synaptic vesicle docking; synaptic transmission, glutamatergic; regulation of short-term neuronal synaptic plasticity; positive regulation of neurotransmitter secretion; amyloid-beta metabolic process; neuromuscular junction development; positive regulation of dendrite extension; regulation of synaptic transmission, glutamatergic; innervation; synaptic vesicle maturation; neurotransmitter secretion; exocytosis; chemical synaptic transmission; synaptic vesicle exocytosis; synaptic vesicle priming; positive regulation of synaptic plasticity; positive regulation of glutamate receptor signaling pathway; regulation of amyloid precursor protein catabolic process; presynaptic dense core vesicle exocytosis; dense core granule priming;
	Sources:Amigo / QuickGO
Orthologs
	23025
	382018
	ENSG00000130477
	ENSMUSG00000034799
	Q9UPW8
	Q4KUS2
	NM_001080421; NM_001387021; NM_001387022; NM_001387023
	NM_001029873
	NP_001073890
	NP_001025044
	Wikidata
View/Edit Human	View/Edit Mouse

Unc-13 homolog A (C. elegans) is a protein that in humans is encoded by the UNC13A gene and in mice by the Munc13-1 gene.